Thermo Fisher Scientific Oligomer A11 Polyclonal Antibody
다양한 종에서 반응하는 Rabbit Polyclonal 항체로, 단백질 또는 펩타이드의 아밀로이드 올리고머를 특이적으로 인식합니다. Western blot, IHC, ELISA 등 다양한 응용에 적합하며, 단량체나 섬유 형태에는 반응하지 않습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | 29 |
| Immunohistochemistry (IHC) | 1–5 µg/mL | 16 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | – | 1 |
| Immunohistochemistry (Frozen) (IHC (F)) | – | 1 |
| Immunohistochemistry - Free Floating (IHC (Free)) | – | 1 |
| Immunocytochemistry (ICC/IF) | – | 13 |
| Flow Cytometry (Flow) | – | 1 |
| ELISA | 0.1–1 µg/mL | 4 |
| Immunoprecipitation (IP) | – | 2 |
| Neutralization (Neu) | Assay-dependent | 1 |
| Dot blot (DB) | 0.1–1 µg/mL | 28 |
| Miscellaneous PubMed (Misc) | – | 11 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Bacteria, Cat, Cynomolgus monkey, Fruit fly, Human, Mouse, Nematode, Rat, Zebrafish |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic molecular mimic of soluble oligomers |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.0 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10376183 |
Product Specific Information
This antibody recognizes amino acid sequence-independent oligomers of proteins or peptides. A11 does not recognize monomers or mature fibers of proteins or peptides. It reacts with soluble AB42 oligomers and does not react with soluble low molecular weight AB40 or AB40 fibrils.
A11 recognizes oligomeric species of several other amyloidogenic polypeptides including AB42, human insulin, prion, polyglutamine, lysozyme, alpha-synuclein, and yeast prion Sup35.
Oligomeric AB42 is recommended as a positive control, while monomeric and fibrillar AB42 are recommended as negative controls.
Target Information
Many degenerative diseases are associated with the accumulation of misfolded proteins known as amyloid fibrils. Soluble amyloid oligomers are considered the principal pathogenic species responsible for amyloid fibril formation, thus playing a key role in neurodegenerative disease pathogenesis.
This anti-oligomer antibody provides a convenient means to assess the significance of oligomers in disease mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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