Thermo Fisher Scientific Tau Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: Assay-dependent

Immunohistochemistry (IHC)

• Tested Dilution: Assay-dependent
• Publications: 1 publication available

Functional Assay

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both structures. Axonal polarity is determined by TAU/MAPT localization within the neuronal cell body domain defined by the centrosome.

Short isoforms contribute to cytoskeletal plasticity, while longer isoforms stabilize microtubules. In its hyper-phosphorylated form, Tau becomes the major component of paired helical filaments (PHF), which form neurofibrillary lesions in Alzheimer’s disease brains. Hyper-phosphorylation impairs Tau’s microtubule-binding function, leading to destabilization and neuronal degeneration.

Tau phosphorylation is mediated by several kinases, including GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also found in neurofibrillary lesions associated with other central nervous system disorders such as Pick’s disease, frontotemporal dementia, cortico-basal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.