Thermo Fisher Scientific IFITM2 Monoclonal Antibody (OTI4E3), TrueMAB
IFITM2 단백질을 인식하는 Mouse IgG2a 단클론 항체로, Western Blot 및 IHC(P) 실험에 적합합니다. 인간 유래 IFITM2 재조합 단백질을 면역원으로 제작되었으며, 항바이러스 연구 및 세포 내 감염 메커니즘 분석에 활용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:2,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E3 |
| Immunogen | Full length human recombinant protein of human IFITM2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
Recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
IFITM2 is an interferon-induced antiviral protein that inhibits viral entry into the host cytoplasm. It allows endocytosis but prevents viral fusion and release of contents into the cytosol.
Active against multiple viruses including:
- Influenza A virus
- SARS-CoV
- Marburg virus (MARV)
- Ebola virus (EBOV)
- Dengue virus (DNV)
- West Nile virus (WNV)
- HIV-1
- Vesicular stomatitis virus (VSV)
It can inhibit viral entry mediated by influenza hemagglutinin, MARV and EBOV GP1,2, SARS-CoV S protein, and VSV G protein.
Additionally, IFITM2 induces cell cycle arrest and apoptosis via caspase activation in a p53-independent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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