Thermo Fisher Scientific IFITM2 Monoclonal Antibody (OTI2B3), TrueMAB
IFITM2 단백질을 인식하는 Mouse Monoclonal Antibody로, Western blot 및 IHC(P) 실험에 적합합니다. 인간 시료에 반응하며, 동결건조 형태로 제공됩니다. 바이러스 진입 억제 연구 및 세포 내 항바이러스 기전 분석에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B3 |
| Immunogen | Full length human recombinant protein of human IFITM2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform desalting using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
IFITM2 is an IFN-induced antiviral protein that inhibits viral entry into host cell cytoplasm by allowing endocytosis but preventing viral fusion and release of viral contents into the cytosol.
It is active against multiple viruses including influenza A virus, SARS-CoV, Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), HIV-1, and vesicular stomatitis virus (VSV).
It can inhibit viral entry mediated by influenza virus hemagglutinin, MARV and EBOV GP1,2, SARS-CoV S protein, and VSV G protein.
Additionally, IFITM2 induces cell cycle arrest and mediates apoptosis via caspase activation in a p53-independent manner.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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