Thermo Fisher Scientific CD185 (CXCR5) Monoclonal Antibody (MU5UBEE), PE, eBioscience

Thermo Fisher Scientific CD185 (CXCR5) Monoclonal Antibody (MU5UBEE), PE, eBioscience

Applications and Tested Dilution

• Application: Flow Cytometry
• Tested Dilution: 5 µL (0.125 µg)/test
• Publications: View 15 publications

Product Specifications

Available Formats

• Unconjugated
• Alexa Fluor 532, 700
• APC, Biotin
• Brilliant UV 395, 615, 737, 805
• Brilliant Violet 421, 480, 605, 786
• eFluor 450, FITC
• NovaFluor Blue, Red, Violet, Yellow series
• PE-Cyanine5, PE-Cyanine7, PE-eFluor 610
• PerCP-eFluor 710
• Super Bright 436, 600, 645, 702
• Request custom conjugation

Product Specific Information

The MU5UBEE monoclonal antibody reacts with human and non-human primate CD185 (CXCR5), also known as Burkitt lymphoma receptor 1 (BLR1). CD185 is a seven-transmembrane G protein-coupled receptor originally identified in Burkitt’s lymphoma. It is expressed on B cells, CD4+ T cells (excluding Th1/Th2), and memory (CD45RO+) T cells.
In tonsil tissue, CD185+ cells co-express CD45RO and activation markers (CD69, ICOS) and can induce antibody production when co-cultured with B cells, indicating their role as follicular helper T cells.
This receptor plays a critical role in lymphocyte trafficking, particularly T cell migration into B cell follicles in response to CXCL13.
The antibody cross-reacts with Rhesus macaque.

Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and tested for flow cytometry of normal human peripheral blood cells.
Recommended Use: 5 µL (0.125 µg) per test (100 µL final volume).
Excitation: 488–561 nm; Emission: 578 nm; Laser: Blue, Green, Yellow-Green
Filtration: 0.2 µm post-manufacturing filtered

Target Information

CXCR5 (C-X-C Chemokine Receptor Type 5, CD185), also known as BLR1, is a G protein-coupled receptor for chemokine BLC. It is specifically expressed in Burkitt’s lymphoma and lymphatic tissues such as lymph node follicles and spleen.
CXCR5 plays an essential role in B cell migration and has been detected in various human and animal tissues including blood, lymph node, spleen, liver, and tonsil.
As a member of the GPCR family, CXCR5 shares the seven transmembrane helix structure and participates in signaling via G-proteins and downstream effectors.
GPCR-related research has led to major pharmaceutical developments, including drugs targeting mental health and allergy pathways.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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