Thermo Fisher Scientific CD200 Monoclonal Antibody (OX104), PE, eBioscience
인간 CD200(OX2)을 인식하는 OX104 단클론 항체로, PE 형광 표지되어 있습니다. 유세포분석(Flow Cytometry)에 최적화되어 있으며, 5 µL(0.25 µg)/test로 사용 가능합니다. B세포, T세포 등 다양한 세포에서 CD200 발현 연구에 활용됩니다.
- 카탈로그번호
- 12-9200-4x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD200 Monoclonal Antibody (OX104), PE, eBioscience
Applications
Tested Application
- Flow Cytometry (Flow)
Tested Dilution
- 5 µL (0.25 µg)/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OX104 |
| Conjugate | PE |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2572702 |
Additional Available Formats
- Unconjugated
- APC
- APC-eFluor 780
- Biotin
- Brilliant Violet 711
- eFluor 450
- FITC
- NovaFluor Blue 660-120S
- NovaFluor Red 685
- NovaFluor Red 710
- NovaFluor Yellow 610
- NovaFluor Yellow 700
- PE-Cyanine7
- PerCP-eFluor 710
- Request custom conjugation
Product Specific Information
Description:
The monoclonal antibody OX104 recognizes human CD200 (OX2), a member of the immunoglobulin superfamily with two Ig domains, a transmembrane and cytoplasmic domain. CD200 is expressed on resting and activated B cells, a subset of T cells, keratinocytes, peripheral and central nerve cells, follicular dendritic cells, and ovarian cells. Interaction with CD200R leads to macrophage activation (IL-6 production), inhibition of mast cell degranulation, reduced TNF-α and IL-13 secretion, and attenuation of lymphocyte activation. It may also play a role in maternal tolerance due to trophoblast expression.
Applications Reported:
- Flow cytometric analysis
Applications Tested:
- Pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells
- Recommended use: 5 µL (0.25 µg) per test
- A test is defined as the amount of antibody that will stain a cell sample in a final volume of 100 µL
- Cell number range: 10⁵–10⁸ cells/test
Excitation/Emission:
- Excitation: 488–561 nm
- Emission: 578 nm
- Compatible Lasers: Blue, Green, Yellow-Green
Filtration:
- 0.2 µm post-manufacturing filtered
Target Information
CD200 is a type-1 membrane glycoprotein with two immunoglobulin domains, belonging to the immunoglobulin superfamily. It is a broadly distributed cell surface glycoprotein interacting with CD200R on myeloid cells, preventing macrophage activation. Homologues exist in herpesviruses and poxviruses. Studies in mouse and rat suggest CD200 regulates myeloid cell activity and delivers inhibitory signals to macrophages. Multiple alternatively spliced transcript variants exist. CD200 dysfunction is associated with Mantle Cell Lymphoma and Primary Hypertrophic Osteoarthropathy.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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