Thermo Fisher Scientific Interferon alpha Monoclonal Antibody (IFNA/6689)
인간 IFN-alpha1에 특이적인 단클론 항체로, WB와 IHC(P) 실험에 적합합니다. 항체는 마우스 IgG1, kappa 형이며, 액상 형태로 200 µg/mL 농도를 가집니다. 세포 내 및 분비 위치 검출에 유용하며 항바이러스 연구에 활용됩니다.
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Thermo Fisher Scientific Interferon alpha Monoclonal Antibody (IFNA/6689)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IFNA/6689 |
| Immunogen | Recombinant human IFNA1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Antibody is stable for 24 months.
- Positive Control: Stimulated human peripheral blood mononuclear cells
- Cellular Localization: Cytoplasm, Secreted
- Specificity Comments:
This monoclonal antibody is specific for human interferon alpha 1 and does not cross-react with human interferon alpha 2.
Interferons are widely used therapeutic agents due to their anti-tumor, anti-viral, and immune-modulatory effects. These cytokines act by binding to the Type 1 Interferon Receptor (IFNAR1).
Down-regulation of IFNAR1, influenced by phosphorylation at Serine 535 and 539, determines cytokine signaling magnitude and duration.
Produced by macrophages, IFN-alphas exhibit antiviral activities and stimulate production of protein kinase and oligoadenylate synthetase.
Target Information
IFN alpha (Interferon alpha) is a Type I interferon, part of a family of structurally related, species-specific proteins found in vertebrates.
Interaction with its receptor activates signaling pathways involved in innate immune response against viral infection.
In humans, the IFN alpha gene is located on chromosome 9.
Type I interferons include 14 alpha isoforms and single beta, omega, epsilon, and kappa isoforms.
Homologous molecules are found in many species, including mammals, birds, reptiles, and fish.
IFN alpha is primarily produced by plasmacytoid dendritic cells and plays a key role in antiviral defense and adaptive immunity modulation.
Dysfunction of IFN alpha is associated with diseases such as Hepatitis C and Hepatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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