Thermo Fisher Scientific Tau Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive control: Cerebrum tissue
• Cellular location: Cytoplasm, cytosol, membrane

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. Its primary function is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules, while the N-terminus binds neural plasma membrane components, suggesting Tau functions as a linker between microtubules and the plasma membrane.

Axonal polarity is influenced by TAU/MAPT localization in the neuronal cell body. Short isoforms contribute to cytoskeletal plasticity, whereas longer isoforms aid in stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), a hallmark of neurofibrillary lesions in Alzheimer’s disease (AD).

Hyper-phosphorylation impairs Tau’s microtubule binding, leading to destabilization and neuronal degeneration in AD. Several kinases phosphorylate Tau, including GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also found in other neurodegenerative disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.