Thermo Fisher Scientific HMGCR Recombinant Rabbit Monoclonal Antibody (JF0981)
HMGCR 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot 및 IHC(P) 적용 가능. 높은 특이성과 민감도, 로트 간 일관성, 동물 유래 성분 무첨가. 콜레스테롤 합성 관련 연구용으로 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:5,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JF0981 |
| Immunogen | Synthetic peptide within Human HMGCR aa 438–489 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809798 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to larger rabbit immune repertoire
Target Information
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, critical for biosynthesis of cholesterol and other isoprenoids. It catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in cholesterol production.
HMGCR is a primary target for statin drugs used to lower cholesterol levels and reduce cardiovascular risk.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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