Thermo Fisher Scientific Transthyretin Recombinant Rabbit Monoclonal Antibody (JF1016)
Transthyretin 단백질 검출용 재조합 토끼 단클론 항체. Western blot과 IHC(파라핀 절편)에 적합. 높은 특이도와 재현성, 로트 간 일관성 제공. 단백질 수송 관련 연구용으로 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JF1016 |
| Immunogen | Synthetic peptide within Human Prealbumin (aa 11–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809799 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned, and individual clones are screened to select the best candidates for production.
Advantages include:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
Transthyretin (TTR), also known as prealbumin, is a plasma protein that functions as a transporter of thyroxine and retinal-binding protein. It is primarily produced in the liver and secreted into the plasma. TTR constitutes approximately 25% of cerebrospinal fluid (CSF) protein, suggesting selective transport across the blood-CSF barrier or synthesis within the central nervous system.
TTR is a component of neuritic plaques, neurofibrillary tangles, and microangiopathic lesions associated with senile cerebral amyloid. Over 40 different TTR gene mutations have been linked to amyloid deposition.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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