Thermo Fisher Scientific Caveolin 1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

PA1-064 detects caveolin 1 from human, canine, hamster, mouse, and rat tissues and cells.
It has been successfully used in Western blot and immunoprecipitation procedures.
By Western blot, this antibody detects an ~22 kDa protein representing caveolin 1 from rat heart protein extract.

The immunogen is a synthetic peptide corresponding to residues M(1) S G G K Y V D S E G H L Y T V P(17) C of human CAV1, a sequence conserved across human, mouse, canine, bovine, and rat.
The PA1-064 immunizing peptide (Cat. # PEP-146) is available for use in neutralization and control experiments.

Target Information

Caveolin-1 (CAV1) is a scaffolding protein within caveolar membranes. It interacts directly with G-protein alpha subunits and regulates their activity.
Caveolin-1 is also involved in T-cell receptor (TCR)-mediated activation and co-stimulatory signaling.
It can bind with DPP4 and induce T-cell proliferation and NF-κB activation in a TCR/CD3-dependent manner.
Mutations in the CAV1 gene are associated with congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, and partial lipodystrophy/congenital cataracts with neurodegeneration syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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