Thermo Fisher Scientific APP Monoclonal Antibody (OTI5F1), TrueMAB

Applications and Tested Dilutions

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor, mediating axonal transport of beta-secretase and presenilin 1.
It plays a key role in neurite growth, neuronal adhesion, and axonogenesis.
APP is a 100–140 kDa transmembrane glycoprotein existing in several isoforms due to alternative splicing.
Proteolytic cleavage by beta- and gamma-secretases generates beta amyloid, the main component of senile plaques—one of the major histopathologic features of Alzheimer’s disease.
Abnormal APP processing is also implicated in Down’s syndrome, early onset familial Alzheimer’s disease, and cerebral hemorrhage.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.