Thermo Fisher Scientific APP Monoclonal Antibody (OTI6B7), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Amyloid Precursor Protein (APP) functions as a cell surface kinesin I membrane receptor, mediating axonal transport of beta-secretase and presenilin 1.
APP is essential for neurite growth, neuronal adhesion, and axonogenesis.
It is a 100–140 kDa transmembrane glycoprotein existing in several isoforms due to alternative splicing.
Proteolytic cleavage by beta- and gamma-secretases generates beta-amyloid, the main component of senile plaques in Alzheimer’s disease.
Abnormal APP processing is also associated with Down’s syndrome, early-onset familial Alzheimer’s disease, and cerebral hemorrhage.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.