Thermo Fisher Scientific ESRRB Monoclonal Antibody (OTI1E6), TrueMAB
인간 ESRRB 단백질을 타겟으로 하는 마우스 단클론 항체로, Western blot에 최적화되어 있습니다. 무보존제 제형이며, 동결건조 형태로 제공됩니다. 재구성 후 1 mg/mL 농도로 사용 가능하며, 줄기세포 자가재생 관련 연구에 적합합니다.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1E6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–252 of human ESRRB produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
ESRRB (steroid hormone receptor ERR2) is involved in maintaining self-renewal and pluripotency of embryonic and trophoblast stem cells through FGF and Wnt signaling pathways.
Upon FGF activation, ESRRB interacts with KDM1A, binding to enhancer sites of ELF5 and EOMES, activating transcription and promoting trophoblast stem cell renewal.
It also regulates rod-specific gene expression and is essential for cell survival.
Defects in ESRRB can cause autosomal recessive deafness (DFNB35).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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