Thermo Fisher Scientific ESRRB Monoclonal Antibody (OTI2D7), TrueMAB
인간 ESRRB 단백질을 인식하는 단클론 항체로, Western blot에 최적화되어 있습니다. 동결건조 형태로 제공되며, 재구성 후 약 1 mg/mL 농도로 사용 가능합니다. 자가 재생 및 줄기세포 다능성 연구에 적합합니다. 연구용으로만 사용됩니다.
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Applications
Tested Application and Dilution
- Western Blot (WB): 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–252 of human ESRRB produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
ESRRB (steroid hormone receptor ERR2) plays a crucial role in maintaining self-renewal and pluripotency of embryonic and trophoblast stem cells via FGF and Wnt signaling pathways.
Upon FGF pathway activation, ESRRB interacts with KDM1A, binding to enhancer sites of ELF5 and EOMES, activating their transcription and promoting trophoblast stem cell self-renewal.
ESRRB also regulates expression of rod-specific genes essential for photoreceptor survival.
Defects in the ESRRB gene are associated with autosomal recessive deafness 35 (DFNB35).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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