Thermo Fisher Scientific PDI Monoclonal Antibody (RL90), Alexa Fluor 555
Alexa Fluor 555로 표지된 PDI 단클론 항체(RL90)로, 인간, 마우스, 랫, 햄스터, 돼지 시료에 반응. 단백질 디설파이드 이성질화효소(PDI) 검출용. ICC/IF에 적합하며, 액상 형태로 4°C 보관. 연구용으로만 사용.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Hamster, Human, Mouse, Pig, Rat |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RL90 |
| Immunogen | Purified rat PDI protein |
| Conjugate | Alexa Fluor™ 555 |
| Excitation / Emission Max | 553 / 568 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2662370 |
Additional Formats
- Unconjugated (MA3-019)
- Alexa Fluor 488 (MA3-019-A488)
- Alexa Fluor 647 (MA3-019-A647)
- Request custom conjugation
Product Specific Information
MA3019A555 detects protein disulfide-isomerase (PDI) from human, rat, porcine, and mouse tissues as well as hamster cells.
The MA3019A555 antigen is purified rat PDI.
Target Information
Protein disulfide isomerase (PDI) is a multifunctional protein that catalyzes the formation, breakage, and rearrangement of disulfide bonds.
At the cell surface, it acts as a reductase that cleaves disulfide bonds of proteins attached to the cell, potentially modifying exofacial protein structures.
Inside the cell, PDI rearranges disulfide bonds of nascent proteins and acts as a chaperone at high concentrations to inhibit aggregation of misfolded proteins.
At low concentrations, it facilitates aggregation (anti-chaperone activity).
PDI may also function with other chaperones in the structural modification of the TG precursor in hormone biogenesis and serves as a structural subunit of enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein (MTTP).
It acts as a receptor for LGALS9, retaining P4HB at the cell surface of Th2 T helper cells, enhancing disulfide reductase activity, and promoting cell migration.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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