Thermo Fisher Scientific HP1 alpha Recombinant Human Monoclonal Antibody (RAB-C133)
HP1 alpha 단백질(CBX5)을 인식하는 인간 유래 재조합 단클론 항체로, ELISA 및 ChIP 분석에 사용 가능. HEK293 세포에서 발현되며 금속 킬레이트 크로마토그래피로 정제됨. 비접합형 액상 형태로 제공되며 4°C 또는 -20°C에서 보관 권장.
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Applications
ELISA (ELISA)
- Tested Dilution: Assay-dependent
ChIP assay (ChIP)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Human / F(ab), kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | RAB-C133 |
| Immunogen | Recombinant antibody (rAb) phage display recognizing CBX5 protein under non-denaturing conditions |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Metal-chelate chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody recognizes CBX5 (Chromobox protein homolog 5) and binds to a folded domain (amino acids 18–75).
CBX5 is a component of heterochromatin that recognizes and binds histone H3 tails methylated at Lys-9 (H3K9me), leading to epigenetic repression.
Target Information
Heterochromatin protein-1 (HP1) is a methyl-lysine binding protein localized at heterochromatin sites, mediating gene silencing.
Mammalian methyltransferases that methylate histone H3 on lysine-9 generate a binding site for HP1 proteins, which act as adaptor molecules in chromatin structure and gene repression.
High-affinity recognition of methylated histone H3 by HP1 requires a functional chromodomain, serving as a specific interaction motif for the methyl epitope on lysine-9.
In vivo, heterochromatin association of HP1 proteins is lost in Suv39h double-primary mouse fibroblasts but restored after reintroduction of catalytically active SUV39H1 HMTase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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