Thermo Fisher Scientific IkB epsilon Recombinant Rabbit Monoclonal Antibody (JM62-63)
IkB epsilon 단백질을 표적하는 재조합 토끼 단클론 항체로 높은 특이성과 민감도를 제공. Western blot 및 IHC(P) 응용에 적합하며, HEK293 세포에서 발현된 IgG 형 항체. 단백질 A로 정제되어 로트 간 일관성이 우수하고 연구용으로 최적화됨.
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Thermo Fisher Scientific IkB epsilon Recombinant Rabbit Monoclonal Antibody (JM62-63)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM62-63 |
| Immunogen | Synthetic peptide within Human IKB epsilon aa 175–224 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810120 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences are cloned from immunoreactive rabbits, and individual clones are screened to select the best candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity to diverse targets due to the larger rabbit immune repertoire
Target Information
NFKB1 or NFKB2 binds to REL, RELA, or RELB to form the NFKB complex. This complex is inhibited by I-kappa-B proteins (NFKBIA or NFKBIB), which trap NF-kappa-B in the cytoplasm.
Phosphorylation of serine residues on I-kappa-B proteins by kinases (IKBKA or IKBKB) targets them for destruction via the ubiquitination pathway, allowing activation of the NF-kappa-B complex.
Activated NFKB translocates into the nucleus and binds DNA at kappa-B-binding motifs (5'-GGGRNNYYCC-3' or 5'-HGGARNYYCC-3').
For some genes, activation requires interaction with transcription factors such as STAT, AP1, and NFAT.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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