Thermo Fisher Scientific PKC beta-1 Recombinant Rabbit Monoclonal Antibody (JM43-26)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences are cloned from immunoreactive rabbits, and individual clones are screened to select the best candidates for production.
Advantages include:

• Improved specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broader immunoreactivity due to the larger rabbit immune repertoire

Target Information

The PKC family of serine/threonine kinases, including PRKCB1 (PKC beta I), is activated by intracellular signal transduction pathways. In humans, at least 12 PKC isoforms are known, differing in structure, tissue distribution, localization, and substrate specificity.
Conventional PKC members (alpha, beta I, beta II, gamma) are Ca²⁺- and phospholipid-dependent. PKC family members phosphorylate diverse protein targets and play key roles in cellular signaling, acting as receptors for phorbol esters (tumor promoters).
PKC beta-1 is involved in various cellular functions such as B cell activation, apoptosis induction, endothelial proliferation, and intestinal sugar absorption. Mouse studies suggest roles in neuronal regulation and stress-related behavior. Multiple alternatively spliced isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.