Thermo Fisher Scientific MVP Recombinant Rabbit Monoclonal Antibody (JM74-73)
Recombinant rabbit monoclonal antibody targeting human MVP protein. Validated for WB and IHC applications. Offers high specificity, sensitivity, and consistent performance. Suitable for detecting multidrug resistance-related MVP expression. For researc...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JM74-73 |
| Immunogen | Synthetic peptide within Human MVP aa 13–62 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% Sodium Azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2810121 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select optimal candidates for production.
Advantages include:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
The MVP (Major Vault Protein) gene encodes a lung resistance-related protein. Vaults are multi-subunit structures potentially involved in nucleo-cytoplasmic transport. MVP mediates drug resistance, possibly via a transport mechanism. It is widely expressed in normal tissues and overexpressed in multidrug-resistant cancer cells, making it a useful marker of clinical drug resistance.
This gene produces two transcripts using alternative exon 2 sequences, but both share the same open reading frame.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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