Thermo Fisher Scientific Human GM-CSF, AOF Recombinant Protein

Thermo Fisher Scientific Human GM-CSF, AOF Recombinant Protein

Applications

• Western Blot (WB): Assay-dependent
• Immunohistochemistry (IHC): Assay-dependent
• ELISA: Assay-dependent
• Functional Assay: Assay-dependent
• Control (Ctrl): Assay-dependent

Product Specifications

Product Specific Information

Carrier-Free

Reconstitution:
Briefly centrifuge vial before opening to bring contents to the bottom. Reconstitute GM-CSF in sterile, distilled water to a concentration of 0.1–1.0 mg/mL. Further dilutions should be made in aqueous buffers supplemented with carrier protein.

Storage:
Lyophilized preparation is stable at 2–8°C but should be kept at -20°C for long-term storage, preferably desiccated. Upon reconstitution, stable for up to one week at 2–8°C. For maximal stability, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles.

Target Information

The GM-CSF gene encodes a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active protein form exists as a homodimer in the extracellular space.
This gene is located within a cluster on chromosome 5q31, associated with the 5q- syndrome and acute myelogenous leukemia. Related genes in the cluster include interleukins 4, 5, and 13.
GM-CSF promotes tissue inflammation, and elevated levels have been reported in SARS-CoV-2 patients with acute respiratory distress syndrome. Mice lacking this gene or its receptor develop pulmonary alveolar proteinosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.