Thermo Fisher Scientific TNF alpha Monoclonal Antibody (68B6A3 L1)

Applications

Immunohistochemistry (IHC)

• Tested Dilution: Assay-dependent
• View 4 publications

ELISA

• Tested Dilution: —
• View 9 publications

Product Specifications

Product Specific Information

This clone can also be referred to as clone number 68B 6A3 1H8 1F2.

Target Information

TNF alpha is a multifunctional proinflammatory cytokine belonging to the tumor necrosis factor (TNF) superfamily. It is mainly secreted by macrophages and binds to receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.
TNF alpha regulates immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. It exists as multimers (dimers, trimers, or pentamers) and shows a single 17 kDa band under non-reducing SDS-PAGE conditions.
Knockout studies in mice indicate its neuroprotective function and tumor necrosis activity. TNF alpha also plays roles in immune responses to bacterial, viral, parasitic, and fungal infections, and is implicated in autoimmune diseases, insulin resistance, and cancer.
It acts synergistically with interferon-gamma in cytotoxicity against certain transformed cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.