Thermo Fisher Scientific IFN gamma Monoclonal Antibody (67F12A8), Biotin

Applications

ELISA (ELISA)

• Assay-dependent
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Miscellaneous PubMed (Misc)

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Product Specifications

Product Specific Information

This product is recommended as a detection antibody in Sandwich ELISA applications.
This clone can also be referred to as clone number 67F 12A8 L1.

Target Information

IFN gamma (Interferon gamma, Type II interferon) is a macrophage activation factor produced primarily by T-lymphocytes and natural killer cells in response to antigens, mitogens, Staphylococcus enterotoxin B, phytohemaglutanin, and other cytokines.
It is a dimeric glycoprotein consisting of two 146 amino acid subunits (~45 kDa homodimer). On SDS-PAGE, IFN gamma appears as 25, 20, and minor 15.5 kDa bands due to differential glycosylation.
Human IFN gamma is species-specific and does not cross-react with mouse.

Functions include:

• Antiviral activity
• Tumor antiproliferative activity
• Induction of class I and II MHC
• Macrophage activation
• Enhanced immunoglobulin secretion by B lymphocytes

IFN gamma regulates cytokine expression and acts synergistically with other cytokines via the JAK-STAT pathway. It shares ~40% sequence homology with mouse IFN gamma and is upregulated by IL2, FGF basic, EGF, and downregulated by vitamin D3 or DMN.
Mutations in the IFN gamma gene are associated with aplastic anemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.