Thermo Fisher Scientific TNF alpha Monoclonal Antibody (68B2B3)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: -
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Immunohistochemistry (Frozen) (IHC (F))

• Tested Dilution: -
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ELISA

• Tested Dilution: Assay-dependent
• View 11 publications

Product Specifications

Product Specific Information

This product is recommended as a capture antibody in Sandwich ELISA applications.
This clone can also be referred to as clone number 68B2B3 BC6.

Target Information

TNF alpha is a multifunctional proinflammatory cytokine belonging to the tumor necrosis factor (TNF) superfamily. It is mainly secreted by macrophages and binds to receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha regulates immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation.
It exists as multimers of two, three, or five noncovalently linked units, showing a single 17 kDa band under non-reducing SDS-PAGE conditions. Knockout studies in mice suggest neuroprotective functions and tumor necrosis induction in tumor-bearing mice.
TNF alpha also plays roles in immune responses to bacterial, viral, parasitic, and fungal infections and in tumor necrosis. It causes cytolysis or cytostasis of certain transformed cells, synergistic with interferon-gamma. TNF alpha has been implicated in autoimmune diseases, insulin resistance, and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.