Thermo Fisher Scientific Phospho-PKR (Thr446) Recombinant Rabbit Monoclonal Antibody (SY230)
Phospho-PKR (Thr446) 인산화 단백질을 특이적으로 인식하는 재조합 토끼 단일클론 항체. Western blot, IHC, ICC/IF에 적합하며 높은 특이성과 로트 간 일관성을 제공. 단백질 A 정제, 1 mg/mL 농도, 4°C 단기 보관 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry / Immunofluorescence (ICC/IF) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | SY230 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Thr446 of Human PKR (aa 421–470) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809380 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal clones for production.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal-origin-free formulation
- Broader immunoreactivity due to the large rabbit immune repertoire
Target Information
EIF2AK2 (PKR) is one of four kinases that phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to environmental stress. It plays a critical role in antiviral defense through activation by double-stranded RNA during viral infection.
PKR functions in:
- IFN-induced innate antiviral response
- Virus-induced apoptosis, cell growth, and differentiation
- Regulation of pathways including NF-κB, p53, p38, and PDGF signaling
PKR is implicated in tumor suppression, malignancy, and neurodegenerative diseases such as Alzheimer’s, Huntington’s, and amyotrophic lateral sclerosis. Viruses can evade PKR’s antiviral effects through inhibitory mechanisms (e.g., influenza virus NS1 protein).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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