Thermo Fisher Scientific P-Selectin Monoclonal Antibody (Psel.KO.2.5), PE
P-selectin(CD62P)을 인식하는 마우스 단클론 항체로, PE 형광 표지되어 유세포분석(Flow Cytometry)에 적합합니다. 인간, 양, 돼지 시료에 반응하며, 단백질 A로 정제되어 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용 가능합니다.
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Applications
- Flow Cytometry (Flow): Neat
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Sheep, Pig |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | Psel.KO.2.5 |
| Immunogen | CD62P transfected 300.19 cells |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation/Emission Max | 565 / 576 nm |
| Form | Lyophilized |
| Concentration | Not determined |
| Purification | Protein A |
| Storage buffer | PBS with 1% BSA, 5% sucrose |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538400 |
Product Specific Information
- Reconstitute with 1 mL of distilled water.
- After reconstitution, store undiluted at 4°C in the dark.
- Shelf life after reconstitution: approximately 18 months.
- For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
- Mouse anti-Human CD62P antibody (clone Psel.KO.2.5) recognizes the CD62P cell surface antigen (~140 kDa glycoprotein, also known as P-selectin).
Target Information
P-selectin (Selectin P, GMP-140, LECAM3, CD62 antigen-like family member) is a 140 kDa type I transmembrane glycoprotein involved in cell rolling regulation. It is stored in Weibel-Palade bodies of endothelial cells and α-granules of platelets. Upon activation by thrombin, histamine, complement 5a, Ca²⁺ ionophores, or adenosine diphosphate, it translocates to the cell surface.
P-selectin mediates adhesion between activated endothelial cells or platelets and leukocytes through calcium-dependent binding to sialylated Lewis blood group carbohydrate antigens. It plays a key role in inflammation, atherogenesis, thrombosis, and tissue destruction. Clinically, it helps distinguish heparin-induced thrombocytopenia with or without thrombosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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