Thermo Fisher Scientific ALDH3A1 Monoclonal Antibody (OTI1B6), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Aldh3A1 belongs to the aldehyde dehydrogenase superfamily, a group of NAD(P)(+)-dependent enzymes that oxidize a wide range of aliphatic and aromatic aldehydes.
It is highly expressed in the stomach and cornea, where it can constitute up to 50% of the water-soluble protein fraction. Aldh3A1 protects the cornea from UV-induced oxidative stress by detoxifying reactive aldehydes and absorbing UV energy.
Studies show that Aldh3A1-deficient mice have normal corneas, but mice lacking both Aldh3A1 and Aldh1A1 exhibit increased cataract formation after UVB exposure, suggesting compensatory roles between these enzymes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.