Thermo Fisher Scientific SSEA1 Monoclonal Antibody (MEM-158), Biotin

Applications

Product Specifications

Additional Formats

• Unconjugated
• APC
• FITC
• PE
• Request custom conjugation

Product Specific Information

This antibody reacts with CD15, a cell membrane molecule 3‑fucosyl‑N‑acetyllactosamine (3‑FAL) strongly expressed on the surface of granulocytes, monocytes, macrophages, and mast cells. It is also present on Langerhans cells and some myeloid precursor cells.

Target Information

CD15 (Lewis X, Le(x); stage specific embryonic antigen‑1, SSEA‑1) is a trisaccharide determinant (3‑fucosyl‑N‑acetyllactosamine) expressed on several glycolipids, glycoproteins, and proteoglycans of various cell types such as granulocytes, mast cells, monocytes, macrophages, gastric mucosa cells, nervous system cells, and various tumour cells.
There are several variants of Lewis X, such as sialyl‑Lewis X or sulphated Lewis X.
Cells with high surface expression of Le(x) antigen exhibit strong self‑aggregation based on calcium‑dependent Le(x)‑Le(x) interaction, which is involved in embryo compaction and autoaggregation of teratocarcinoma cells.
Sialyl‑Le(x) and its isomer sialyl‑Le(a) are ligands of selectins.
CD15 expression has been extensively used to confirm diagnosis of Hodgkin’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.