Thermo Fisher Scientific CD18 Monoclonal Antibody (MEM-48), Biotin
Human CD18 항원을 인식하는 Mouse IgG1 단일클론 항체로, Biotin 결합 형태입니다. WB, IHC, Flow Cytometry 등 다양한 응용에 적합하며, 세포 부착 및 신호전달 연구에 활용됩니다. 4°C 보관, 1 mg/mL 농도, TBS(pH8) 버퍼 포함.
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Thermo Fisher Scientific CD18 Monoclonal Antibody (MEM-48), Biotin
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | Assay-dependent |
| Flow Cytometry (Flow) | 1–3 µg/mL |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MEM-48 |
| Immunogen | Leucocytes from a patient suffering from a LGL type leukaemia |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Size-exclusion chromatography |
| Storage Buffer | TBS, pH 8 |
| Contains | 15 mM sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1071392 |
Available Formats
Product Specific Information
This antibody recognizes an extracellular epitope involving residues 534–546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit). CD18 is a 90–95 kDa type I transmembrane protein expressed on all leukocytes.
It will not cross-react with canine.
Target Information
CD18 (integrin beta 2 subunit) is a 90 kDa type I transmembrane protein expressed on all leukocytes. It forms heterodimers with CD11 molecules (CD11a–d) to constitute leukocyte (β2) integrins:
- αLβ2 (CD11a/CD18, LFA-1)
- αMβ2 (CD11b/CD18, Mac-1, CR3)
- αXβ2 (CD11c/CD18)
- αDβ2 (CD11d/CD18)
These integrins mediate cell adhesion and signaling essential for leukocyte migration and intercellular contact.
Defects in CD18 cause leukocyte adhesion deficiency type I (LAD1). Severe reduction of CD18 expression can lead to psoriasiform skin disease. CD18 is also targeted by Mannheimia haemolytica leukotoxin, mediating leukotoxin-induced cytolysis.
Two transcript variants encoding CD18 protein have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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