Thermo Fisher Scientific ALK Monoclonal Antibody (OTI1A4), TrueMAB
인간 ALK 단백질을 인식하는 Mouse monoclonal antibody로 Western blot, IHC, Luminex 등 다양한 응용에 적합합니다. 동결건조 형태이며, PBS buffer와 trehalose를 포함하고 보존제가 없습니다. 뇌 발달 관련 연구 및 암 관련 ALK 변이 연구에 유용합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:2,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | |
| Luminex (LUM) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1300–1620 of human ALK produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | –20 °C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
- For conjugation experiments using this carrier-free antibody, perform an additional desalting step.
(Recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882)
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a vital role in brain development.
Mutations, rearrangements, and amplifications of the ALK gene are associated with several tumors, including:
- Anaplastic large cell lymphoma
- Neuroblastoma
- Non-small cell lung cancer
Chromosomal rearrangement often leads to fusion of the ALK gene (chromosome 2) with the nucleophosmin (NPM) gene (chromosome 5), producing the oncogenic NPM‑ALK fusion protein.
ALK encodes a receptor protein-tyrosine kinase with transmembrane and extracellular domains, showing high sequence similarity to LTK.
It is essential for neuronal development and signaling in the nervous system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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