Thermo Fisher Scientific PYGL Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000
• Publications: References

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:30–1:150
• Publications: References

Product Specifications

Product Specific Information

The antibody detects endogenous levels of total PYGL protein.

Target Information

This gene encodes a homodimeric protein that catalyzes the cleavage of alpha-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. The protein transitions from inactive phosphorylase B to active phosphorylase A through phosphorylation at serine 15. Enzyme activity is regulated by allosteric effectors and hormonal control. Humans possess three glycogen phosphorylase genes encoding distinct isozymes expressed in liver, brain, and muscle. The liver isozyme maintains systemic glycemic balance, while the brain and muscle forms serve their respective tissues. In glycogen storage disease type VI (Hers disease), mutations in liver glycogen phosphorylase disrupt glycogen-to-glucose conversion, leading to moderate hypoglycemia, mild ketosis, growth retardation, and hepatomegaly. Alternative splicing produces multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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