Thermo Fisher Scientific Phospho-CtIP (Ser327) Polyclonal Antibody
인간 CtIP 단백질의 Ser327 인산화 형태를 특이적으로 인식하는 rabbit polyclonal 항체. Western blot에 적합하며, lambda-phosphatase 처리 시 신호가 제거됨. BRCA1 상호작용 연구 및 DNA 손상 반응 연구에 활용 가능.
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Thermo Fisher Scientific Phospho-CtIP (Ser327) Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:1000
Publications: - [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser327 of human CtIP, conjugated to keyhole limpet hemocyanin (KLH) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.25 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 10mM HEPES, pH 7.5, with 100µg/mL BSA, 50% glycerol, 150mM NaCl |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942855 |
Product Specific Information
This antibody is specific for endogenous levels of the ~100 kDa CtIP protein phosphorylated at Ser327. Immunolabeling is completely eliminated by treatment with lambda-phosphatase.
Target Information
CtIP is a 125 kDa protein originally found to interact with transcription repressor CtBP through the PLDLS motif (CtBP-Interacting Protein), suggesting a role in transcription regulation. It also interacts with BRCA1 via the C-terminal BRCT domains, indicating a potential tumor suppressor function. The CtIP–BRCA1 interaction can be disrupted by DNA-damaging agents such as UV or gamma irradiation.
Li et al. (Nature 406, 210–215, 2000) demonstrated that ATM phosphorylates CtIP at serine residues 664 and 745; mutation of these sites prevents BRCA1 dissociation from CtIP, leading to persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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