Thermo Fisher Scientific MECP2 Polyclonal Antibody
MECP2 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 인간·마우스·영장류 시료에 반응합니다. Western blot 및 면역조직화학(파라핀) 분석에 적합하며, 고순도 IgY 분획으로 정제된 액상 형태입니다. 단기 4°C, 장기 -20°C 보관 권장.
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Thermo Fisher Scientific MECP2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Chicken / IgY |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Full length human recombinant MeCP2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 20 mg/mL |
| Purification | IgY fraction |
| Storage Buffer | PBS |
| Contains | 5 mM sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2942858 |
Product Specific Information
Specific for endogenous levels of the MeCP2 protein. Due to usually high charge, the protein runs at approximately 75 kDa in SDS-PAGE of mouse brain lysates.
Target Information
MECP2 belongs to a family of nuclear proteins (including MBD1, MBD2, MBD3, and MBD4) that have a methyl-CpG binding domain. MECP2 binds specifically to methylated DNA, a key modification of eukaryotic genomes essential for mammalian development. It can repress transcription from methylated gene promoters. Unlike other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensable in stem cells but essential for embryonic development. Mutations in the MECP2 gene are the primary cause of Rett syndrome, a progressive neurological developmental disorder and a common cause of mental retardation in females.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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