Thermo Fisher Scientific Phospho-ErbB4 (Tyr1056) Polyclonal Antibody
Phospho-ErbB4 (Tyr1056) 폴리클로날 항체로, 인산화된 HER4 단백질을 특이적으로 검출. Western blot 및 ICC/IF에 적합하며, 인간·마우스·랫트 반응성. 고순도 정제 및 안정적 PBS/glycerol 저장용액 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ERBB4 (Accession Q15303), corresponding to amino acid residues around phosphorylated Tyr1056 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817484 |
Product Specific Information
Antibody detects endogenous levels of HER4 only when phosphorylated at Tyr1056.
Target Information
Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine kinase subfamily that includes EGFR, ERBB2, and ERBB3.
ERBB4 binds and is activated by neuregulins and other factors, inducing cellular responses such as mitogenesis and differentiation.
ErbB4 mediates signal transduction in eukaryotic cells, regulating metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.
It is predominantly expressed in breast carcinoma cell lines and normal tissues such as skeletal muscle, heart, pituitary, brain, and cerebellum.
ErbB4 levels are elevated in certain human tumor cell lines, suggesting a role in malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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