Thermo Fisher Scientific Phospho-CHK2 (Ser33, Ser35) Polyclonal Antibody
인산화된 CHK2(Ser33, Ser35)를 인식하는 Rabbit Polyclonal 항체로, Western blot 및 ELISA에 적합. DNA 손상 반응 연구에 활용 가능하며, 높은 특이성과 재현성을 제공. PBS/glycerol 용액 상태로 -20°C에서 보관.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around S33 & S35 of human Chk2 (NP_009125.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.98 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914856 |
Product Specific Information
- Positive test controls: HeLa, HeLa+UV, 293, 293+UV
- Subcellular localization: Nucleus, PML body, nucleoplasm
- Immunogen sequence: SSQSQ
Target Information
CHEK2 (CHK2) is a serine/threonine kinase involved in the DNA damage checkpoint pathway. Mutations in CHK2 are linked to various cancers, including Li-Fraumeni syndrome, sarcomas, breast cancer, and brain tumors.
CHK2 is activated by DNA damage and phosphorylates modulators of cell cycle control, such as tumor suppressor proteins and BRCA1, aiding in DNA repair and cell survival.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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