Thermo Fisher Scientific Phospho-Syk (Tyr323) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Target localization: Cell membrane, Cytoplasm, Cytosol
• Immunogen sequence: NPYEP

Target Information

Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are considered potential drug targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer.
Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcεRI) triggering, and phosphorylates downstream adaptor proteins, providing docking sites for signaling pathways such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes.
Syk binds to receptor assemblies through interactions of its SH2 domains with ITAM motifs of the receptor, which have been phosphorylated by Src-family kinases. These kinases also activate Syk by phosphorylation of its activation loop.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.