Thermo Fisher Scientific Phospho-Syk (Tyr323) Polyclonal Antibody
Phospho-Syk (Tyr323) 폴리클로날 항체로, 인산화된 Syk 단백질(Y323 부위)을 특이적으로 인식합니다. Western blot 및 ELISA에 사용 가능하며, 인간 단백질에 반응합니다. PBS/glycerol 용액 형태로 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic phosphorylated peptide around Y323 of human Syk (NP_003168.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.556 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2914853 |
Product Specific Information
- Target localization: Cell membrane, Cytoplasm, Cytosol
- Immunogen sequence: NPYEP
Target Information
Spleen tyrosine kinase (SYK), along with ZAP70, are cytoplasmic tyrosine kinases that are considered potential drug targets for allergic disorders and autoimmune diseases. SYK may also play a role in cancer.
Syk translocates to the plasma membrane upon B cell antigen receptor (BCR) or high-affinity IgE receptor (FcεRI) triggering, and phosphorylates downstream adaptor proteins, providing docking sites for signaling pathways such as calcium mobilization, cytoskeleton remodeling, or transcription of specific genes.
Syk binds to receptor assemblies through interactions of its SH2 domains with ITAM motifs of the receptor, which have been phosphorylated by Src-family kinases. These kinases also activate Syk by phosphorylation of its activation loop.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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