Thermo Fisher Scientific Amyloid Beta 1-16 Monoclonal Antibody (Ab5)
Amyloid Beta 1-16을 인식하는 마우스 단클론 항체로, Western blot, IHC, ICC, ELISA, IP에 적합합니다. 인간 및 마우스 시료에 반응하며, Alzheimer’s disease 관련 연구에 활용됩니다. PBS buffer에 보존된 액상 형태로, 단백질 A 정제 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–10 µg/mL |
| Immunohistochemistry (IHC) | 1–10 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–10 µg/mL |
| ELISA | Assay-dependent |
| Immunoprecipitation (IP) | 1–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | Ab5 |
| Immunogen | Aggregated Amyloid beta 1-42, fibrillar Amyloid beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.0 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
This antibody recognizes an epitope within Ab1–16 as well as other Ab peptides: Ab37, Ab38, Ab39, Ab40, and Ab42.
Note: When administered to young Tg2576 mice with minimal Ab deposition and to older mice with higher Ab loads, this antibody reduced Ab accumulation in the brain.
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease.
Abeta peptide (40–43 amino acids) is generated from the beta-amyloid precursor protein (beta APP) through sequential cleavage by beta-secretase (BACE) and gamma-secretase.
- Beta-secretase (BACE): Cleaves the extracellular domain of beta APP after activation by furin.
- Gamma-secretase: Cleaves the membrane-bound remnant of beta APP to generate amyloid beta peptide.
- Complex components: Presenilin-1, Presenilin-2, and Nicastrin are key subunits of gamma-secretase complex.
Amyloid beta deposits are characteristic of Alzheimer’s disease and are also detected in Lewy body dementia, Down’s syndrome, Dutch-type amyloidosis, cerebral amyloid angiopathy, and the Guam Parkinson-Dementia complex.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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