Thermo Fisher Scientific CDK4 Polyclonal Antibody
Human CDK4 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC/IF, IP 등 다양한 응용에 적합합니다. 보존제가 포함되지 않아 필요 시 sodium azide를 추가할 수 있습니다. 세포 증식 조절 관련 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:300–1:10,000 |
| Immunoprecipitation (IP) | 4–8 µL/mg of lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the N-terminus of Human CDK4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787775 |
Product Specific Information
- This product is preservative-free.
- To prevent contamination, it is recommended to add sodium azide (final concentration 0.05%–0.1%).
- This antibody specifically recognizes Human CDK4.
Target Information
CDK4/cyclin D3 serine/threonine kinase is a dimeric protein complex. CDK4, a member of the cyclin-dependent protein kinase family, regulates cell proliferation during the G1 phase of the cell cycle. It forms a complex with D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 mediates phosphorylation of the C-terminal region of the Rb protein, leading to transcriptional repression of the E2F complex. CDC37 and HSP90 preferentially associate with CDK4 not bound to D-type cyclins. SMAD3 serves as a physiological substrate for CDK4 and CDK2. Although both CDK4 and CDK6 phosphorylate Rb protein, they exhibit different residue selectivity—CDK6 phosphorylates Thr821, while CDK4 phosphorylates Thr826.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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