Thermo Fisher Scientific HDAC8 Recombinant Rabbit Monoclonal Antibody (JJ0845)
HDAC8 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC/IF, Flow cytometry에 적합합니다. 높은 특이성과 일관된 로트 간 재현성을 제공하며, 비동물 유래 포뮬레이션으로 생산됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- MA532422
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ0845 |
| Immunogen | Synthetic peptide within Human HDAC8 (aa 51–100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809700 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
In intact cells, DNA closely associates with histones and other nuclear proteins to form chromatin. Chromatin remodeling is a key component of transcriptional regulation, largely influenced by histone acetylation.
Acetylation of histone lysine residues increases DNA accessibility to transcription factors, while deacetylation is associated with transcriptional silencing.
Several mammalian proteins function as nuclear histone acetylases, including GCN5, PCAF, p300/CBP, HAT1, and TAF II p250.
HDAC8, isolated from human kidney, is a histone deacetylase with unique tissue distribution and nuclear localization. It plays a role in tissue development and cancer etiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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