Thermo Fisher Scientific Cdc37 Recombinant Rabbit Monoclonal Antibody (JJ087-06)
Recombinant rabbit monoclonal antibody recognizing Cdc37 protein. Validated for WB, IHC (Paraffin), and Flow Cytometry. Offers high specificity, lot-to-lot consistency, and animal origin-free formulation. Suitable for detecting Cdc37 in human, mouse, a...
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:50–1:100 |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ087-06 |
| Immunogen | Synthetic peptide within Human Cdc37 (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809702 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed, followed by screening to select optimal clones.
Advantages include:
- Enhanced specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to the extensive rabbit immune repertoire
Target Information
Cdc37 is a key regulator of the cell division cycle through its interaction with cyclin-dependent kinases (CDKs). It also participates in signaling pathways involving kinases such as v-Src, casein kinase II, MPS1 kinase, and the sevenless receptor tyrosine kinase.
Cdc37 (also known as p50) forms complexes with HSP90 and various kinases, including Src-family kinases (Fyn, Yes, Fes, Lck, Fgr), Raf, and pp60v-src. It acts as a molecular chaperone both independently and in cooperation with HSP90, facilitating the binding of HSP90 to Cdk4.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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