Thermo Fisher Scientific SRPK2 Polyclonal Antibody
SRPK2 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며 인간 시료에 반응. 항원 친화 크로마토그래피로 정제된 액상 형태로, 안정적인 장기 보관 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human SRPK2. Recombinant protein control fragment (Product #RP-91439) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.10 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2647929 |
Product Specific Information
Immunogen sequence:
QQLDDEDDDE EDCPNPEEYN LDEPNAESDY TYSSSYEQFN GELPNGRHKI PESQFPEFST SLFSGSLEPV ACGSVLSEGS PLTEQEESSP SHDRSRTVSA SSTGDLPKAK TRAADLLVNP L
Highest antigen sequence identity to the following orthologs:
- Mouse: 86%
- Rat: 83%
Target Information
SRPK2, along with SRPK1, is most likely the cellular protein kinase mediating HBV core protein phosphorylation during viral infection. It represents an important host cell target for therapeutic intervention in HBV infection.
Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression through phosphorylation of SRSF2, leading to suppression of p53/TP53 phosphorylation.
Phosphorylates ACIN1 and redistributes it from nuclear speckles to nucleoplasm, resulting in cyclin A1 up-regulation.
Plays an essential role in spliceosomal B complex formation via phosphorylation of DDX23/PRP28.
Negatively regulates HBV replication by reducing packaging efficiency of pregenomic RNA (pgRNA) without affecting viral core particle formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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