Thermo Fisher Scientific Unc18-2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human Unc18-2. Recombinant protein control fragment (Product #RP-90659). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Unc18-2,uniProtId:Q15833-1,ncbiNodeId:9606,antigenRange:110-210,antigenLength:593,antigenImageFileName:PA5-53322_Unc18-2_Q15833-1_Rabbit.svg,antigenImageFileNamePDP:PA5-53322_Unc18-2_Q15833-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2649268

Product Specific Information

Immunogen sequence: CPEPLFSELG RSRLAKVVKT LKEIHLAFLP YEAQVFSLDA PHSTYNLYCP FRAEERTRQL EVLAQQIATL CATLQEYPAI RYRKGPEDTA QLAHAVLAKL N

Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 96%.

Target Information

This gene encodes a member of the STXBP/unc-18/SEC1 family. The encoded protein is involved in intracellular trafficking, control of SNARE (soluble NSF attachment protein receptor) complex assembly, and the release of cytotoxic granules by natural killer cells. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.