Thermo Fisher Scientific Resistin (RETN) Monoclonal Antibody (RETN/4327)
인간 Resistin 단백질을 인식하는 마우스 단클론 항체로, IHC(P), IHC(PFA), Peptide Array에 사용 가능. 단백질 A/G로 정제된 액상 형태이며, PBS 완충액에 보관. 비만 및 인슐린 저항성 연구에 유용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RETN/4327 |
| Immunogen | Recombinant fragment of human RETN protein (around aa 19–108) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Adipose tissue acts as an energy reserve in animals and is tightly regulated. Adipocytes produce and secrete various physiologically important proteins, including lipoprotein lipase (LPL), leptin, Acrp30, perilipin, and resistin.
Resistin, also known as Adipocyte Secreted Factor (ADSF) and FIZZ3, is a cytokine specifically secreted by adipocytes. Although its function is not fully understood, resistin appears to play key paracrine roles and is implicated in type 2 diabetes.
In obese and diabetic mice, serum resistin levels are elevated, antagonizing insulin action. Studies indicate that resistin induces insulin resistance and glucose intolerance. Resistin gene expression depends on C/EBP alpha, with coactivators CBP and p300 acetylating histones at the resistin promoter, facilitating transcriptional activation.
Additionally, PPAR gamma and RXR ligands have been shown to downregulate resistin expression in adipocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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