Thermo Fisher Scientific Resistin (RETN) Monoclonal Antibody (RETN/4324)
Thermo Fisher Scientific의 Resistin (RETN) 단클론 항체는 인간 시료에 반응하며, Western blot과 면역조직화학(PFA 고정)에 적합합니다. Recombinant human RETN 단백질(aa 19-108)을 면역원으로 제작되었으며, Protein A/G로 정제된 액상 항체입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | RETN/4324 |
| Immunogen | Recombinant fragment of human RETN protein (around aa 19–108) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Adipose tissue serves as an energy reserve and is tightly regulated. Adipocytes produce and secrete several physiologically important proteins such as lipoprotein lipase (LPL), leptin, Acrp30, perilipin, and resistin.
Resistin, also known as Adipocyte Secreted Factor (ADSF) and FIZZ3, is a cytokine secreted specifically by adipocytes. Although its function is not fully understood, resistin appears to play key paracrine roles and is implicated in type 2 diabetes.
Studies have shown that serum resistin levels are elevated in obese, diabetic mice, exerting antagonistic effects on insulin. Resistin expression requires C/EBP alpha, with coactivators CBP and p300 acetylating histones at the resistin promoter, suggesting chromatin activation for transcription. PPAR gamma and RXR ligands have been shown to downregulate resistin expression in adipocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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