Thermo Fisher Scientific KLRG1 Monoclonal Antibody (13F12F2), Brilliant Ultra Violet 395, eBioscience
인간 KLRG1 단백질에 특이적인 13F12F2 클론 단일클론 항체. Brilliant Ultra Violet 395 형광체 결합으로 유세포분석(Flow Cytometry)에 최적화. 사전 희석된 액상 형태로 제공되며, 5 µL/test 사용 권장. 연구용으로만 사용 가능.
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Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (1.0 µg)/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 13F12F2 |
| Conjugate | Brilliant Ultra Violet™ 395 |
| Excitation / Emission Max | 347 / 399 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.2, with BSA |
| Contains | 0.09% sodium azide |
| Storage conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2937089 |
Additional Formats Available
- Alexa Fluor 488
- Alexa Fluor 647
- APC
- APC-eFluor 780
- Brilliant UV 737
- Brilliant Violet 480
- Brilliant Violet 786
- Functional Grade
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 600
- Super Bright 702
- Custom conjugation available
Product Specific Information
This 13F12F2 monoclonal antibody reacts with human killer cell lectin-like receptor subfamily G, member 1 (KLRG1), a type II transmembrane inhibitory receptor of the C-type lectin superfamily containing an ITIM domain. It is expressed on subsets of γδ T cells, NK (CD56dim), CD8+, and CD4+ T cells. KLRG1 is primarily found in effector/memory phenotype cells that are short-lived but capable of immediate effector function. Cadherin-E, -N, and -R serve as ligands for KLRG1, and their interaction inhibits cytolytic activity and proliferation. The percentage of KLRG1-positive cells can vary depending on antigen experience.
Clones 13F12F2 and 13A2 recognize a similar epitope based on cross-blocking studies.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-diluted and validated for flow cytometric analysis of normal human peripheral blood cells. Recommended use: 5 µL (1.0 µg) per test (100 µL final volume; 10⁵–10⁸ cells/test).
Fluorochrome Information:
Brilliant Ultra Violet™ 395 (BUV395) emits at 395 nm and is designed for cytometers equipped with a 355 nm UV laser. Ensure instrument compatibility before use.
When using multiple polymer dye-conjugated antibodies (Super Bright, Brilliant Violet™, Brilliant Ultra Violet™), use Super Bright Complete Staining Buffer (Cat. SB-4401-42) or Brilliant Stain Buffer™ (Cat. 00-4409-75) to minimize non-specific interactions.
Excitation: 350 nm
Emission: 395 nm
Laser: Ultraviolet Laser
BRILLIANT ULTRA VIOLET™ is a trademark or registered trademark of Becton, Dickinson and Company or its affiliates, used under license. Powered by Sirigen™.
Target Information
KLRG1 (Killer cell lectin-like receptor G1, MAFA, 2F1-Ag) is a homodimeric member of the lectin-like type 2 transmembrane receptor family containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in the cytoplasmic domain. These ITIMs interact with SH2 domains of phosphatases such as SHP-1. KLRG1 is an inhibitory receptor expressed on NK cells and certain T cells, involved in tumor and virus-infected cell lysis, and mediating humoral and cell-mediated immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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