Thermo Fisher Scientific CRX Polyclonal Antibody
CRX 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot과 면역세포염색에 적합합니다. 항원 친화 크로마토그래피로 정제되어 높은 순도(>95%)를 갖습니다. 인간 및 생쥐 시료에 반응하며, PBS/glycerol 완충액에 보관됩니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human CRX |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720532 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that regulates the expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin. CRX binds the OTX motif (TAATCC/A) upstream of photoreceptor genes. It is also expressed in pinealocytes of the pineal gland and may regulate circadian activity by controlling melatonin synthesis genes. CRX(-) mice show disrupted circadian rhythms. The human CRX gene maps to chromosome 19q13.3, within the cone-rod dystrophy-2 (CORD2) locus. Mutations in CRX are associated with cone-rod dystrophy (CORD), Leber congenital amaurosis (LCA), and retinitis pigmentosa (RP). All known CRX mutations cause disease in heterozygotes, though no correlation between phenotype and mutation type is established. Missense mutations affect the homeobox domain, while frameshift mutations impact the OTX domain.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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