Thermo Fisher Scientific Tyrosinase Recombinant Rabbit Monoclonal Antibody (TYR, 2024R)
Recombinant rabbit monoclonal antibody against human Tyrosinase (TYR). Validated for IHC (paraffin). Provides high specificity and reproducibility. Supplied as liquid, unconjugated form, 200 µg/mL concentration. For research use only.
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Applications and Tested Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | TYR, 2024R |
| Immunogen | Recombinant human full-length tyrosinase (TYR) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | 4°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For immunohistochemistry using PFA-fixed tissues, incubate the antibody for 30 minutes at room temperature. Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
The enzyme encoded by the TYR gene catalyzes the first two steps and at least one subsequent step in the conversion of tyrosine to melanin. It exhibits both tyrosine hydroxylase and dopa oxidase activities and requires copper for function. Mutations in this gene cause oculocutaneous albinism, while nonpathologic polymorphisms contribute to variations in skin pigmentation. The human genome also contains a pseudogene similar to the 3′ half of this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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