Thermo Fisher Scientific GPR182 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: 20 µg/mL
• 참고: Heat-induced antigen retrieval in pH 6.0 citrate buffer 권장.
  1. 1차 항체 처리 후, biotinylated 2차 항체 및 alkaline phosphatase-streptavidin, chromogen으로 검출.

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

Percent identity with other species (BLAST analysis):

• Human, Gorilla, Gibbon, Monkey: 100%
• Elephant: 94%
• Marmoset, Bat, Panda, Rabbit, Horse: 89%
• Mouse, Rat, Hamster, Pig: 83%

Target Information

Adrenomedullin (ADM) is a hypotensive peptide belonging to a peptide superfamily including calcitonin gene-related peptide (CGRP) and amylin.
Originally identified in the adrenal medulla, ADM is expressed in most contractile cells and upregulated during sepsis and ischemia.

Three distinct receptors bind ADM:

• ADM receptor (L1)
• RDC-1
• Calcitonin Receptor-Like Receptor (CRLR)

CRLR associates with receptor activity-modifying proteins (RAMPs):

• RAMP1 → CGRP binding
• RAMP2/3 → ADM binding

ADM receptor is a seven-transmembrane G protein-coupled receptor, highly expressed in heart, brain, skeletal muscle, immune system, adrenal gland, and liver. It mediates ADM signaling through G proteins that activate adenylate cyclase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.