Thermo Fisher Scientific Involucrin (Squamous Cell Terminal Differentiation Marker) Monoclonal Antibody (SPM259)
Involucrin 단백질을 표적하는 SPM259 단클론 항체로, 인간 및 다양한 종에 반응합니다. IHC, ICC, Flow Cytometry 등 다중 응용에 적합하며, 단백질 A/G로 정제된 액상 형태입니다. 연구용으로만 사용됩니다.
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Thermo Fisher Scientific Involucrin Monoclonal Antibody (SPM259)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 0.1–0.2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Dog, Human, Non-human primate, Pig |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM259 |
| Immunogen | Purified involucrin from human keratinocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Mouse
Target Information
Involucrin is a component of the keratinocyte crosslinked envelope, found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. It is expressed in stratified squamous epithelia, including the cornea.
In normal epidermis, involucrin is first expressed in upper spinous layers and in keratinocyte cultures by cells that have left the basal layer.
Abnormal expression is observed in squamous cell carcinomas and premalignant lesions, with reduced levels in severe dysplasias of the larynx and cervix.
The involucrin gene is mapped to chromosome 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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