Thermo Fisher Scientific Involucrin (Squamous Cell Terminal Differentiation Marker) Monoclonal Antibody (IVRN/827)
Human Involucrin 단백질을 인식하는 Mouse Monoclonal Antibody (Clone IVRN/827). IHC, ICC/IF, Flow Cytometry에 적합. Protein A/G로 정제된 액상형 항체로, PBS(pH 7.4)에 보존제 없이 -20°C에서 보관. 연구용으로만 사용 가능.
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Thermo Fisher Scientific Involucrin Monoclonal Antibody (IVRN/827)
Applications & Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | IVRN/827 |
| Immunogen | Purified involucrin from human keratinocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Involucrin is a component of the keratinocyte crosslinked envelope, found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. It is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, involucrin is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions and is reduced in severe dysplasias of the larynx and cervix. The gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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